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Key Largo is an island in the upper Florida Keys archipelago and, at 33 miles (53 km) long, the largest of the Keys. It is also the northernmost of the Florida Keys in Monroe County, and the northernmost of the Keys connected by U.S. Highway 1 (the Overseas Highway). Its earlier Spanish name was Cayo Largo,meaning Long Key.

Key Largo is connected to the mainland in Miami-Dade County by two routes. The Overseas Highway, which is U.S. Highway 1, enters Key Largo at Jewfish Creek near the middle of the island and turns southwest. Card Sound Road connects to the northern part of Key Largo at Card Sound Bridge and runs southeastward to connect with County Road 905, which runs southwest and joins U.S. 1 at about mile marker 106. These routes originate at Florida City on the mainland.

Key Largo is a popular tourist destination and calls itself the "Diving Capital of the World" because the living coral reef a few miles offshore attracts thousands of scuba divers and sport-fishing enthusiasts. Key Largo's proximity to the Everglades also makes it a premier destination for kayakers and ecotourists. Automotive and highway pioneer and Miami Beach developer Carl G. Fisher built Key Largo's famous Caribbean Club in 1938 as his last project.

The island gained fame as the setting for the 1948 Humphrey Bogart-Lauren Bacall film Key Largo, although it was filmed entirely on a Warner Brothers sound stage in Hollywood. The island's post office in Rock Harbor, which had been named after a nearby cove, changed its name to Key Largo after the film's success and pressure from local businesmen. It did this so that everyone living north of Tavernier would have a Key Largo address and the cancellation would say Key Largo instead of Rock Harbor.